Scan May Reveal Early Stages of Alzheimer’s Disease

There is new research which suggests that an eye scan may be able to show the beginning stages of Alzheimer’s disease (AD).1 Neuroscience researchers have found peripheral areas of beta amyloid plaque formation in the retina, similar to those seen in the brain of patients with AD. Beta amyloid plaques are the primary pathological finding in AD, and when occurring in the brain cause toxic effects to neurons, which is thought to be the underlying mechanism by which AD progresses.

The number of people projected to be diagnosed with AD within the next 30 years is staggering, 15 million – according the American Alzheimer’s Association. The ability to screen for individuals at higher risk is ever more important. This could also help screen individuals who may be more susceptible to early treatment interventions in the future.

Study Results

The study showed that a non-invasive eye scan can be used to uncover signs of AD years before symptoms manifest. The eye scan is not a simple ophthalmologic exam that would typically be conducted in a doctor’s office. The scan used in the study was a high-definition scanner developed specifically for the study. The scan revealed beta amyloid plaques, which may be able to be used in the future as a diagnostic test for AD.

Curcumin used Instead of Radioactive Dye

Typically, the way AD is diagnosed definitively is through autopsy. Positron emission tomography (PET) scans are being used to a minor degree on living patients, but the scans are expensive and invasive. Patients have to be injected with radioactive dye, which allows the scans to register the beta amyloid. The researchers of the current study, teamed up with a neuroimaging group, NeuroVision, to develop a scan which would allow visualization of the beta amyloid plaques without the use of radioactive dye. They used curcumin as an alternative. Patients undergoing the eye scan would drink curcumin, and the curcumin causes the beta amyloid in the retina to light up on the scans.

Source

1. Koronyo Y, Biggs D, Barron E, et al. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease. JCI Insight. 2017;2(16)

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Node Smith, associate editor for NDNR, is a fifth year naturopathic medical student at NUNM, where he has been instrumental in maintaining a firm connection to the philosophy and heritage of naturopathic medicine among the next generation of docs. He helped found the first multi-generational experiential retreat, which brings elders, alumni, and students together for a weekend camp-out where naturopathic medicine and medical philosophy are experienced in nature. Three years ago he helped found the non-profit, Association for Naturopathic ReVitalization (ANR), for which he serves as the board chairman. ANR has a mission to inspire health practitioners to embody the naturopathic principles through experiential education. Node also has a firm belief that the next era of naturopathic medicine will see a resurgence of in-patient facilities which use fasting, earthing, hydrotherapy and homeopathy to bring people back from chronic diseases of modern living; he is involved in numerous conversations and projects to bring about this vision.

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